The high court is located in the Real Chancillería (Royal Chancellery) of Granada, a historic building unique in Spain for being the only structure built as a court of law that continues serving the same function. In 1500, the Catholic Monarchs decreed that the Chancellery or high court, then located in Ciudad Real, was to be moved to Granada. The decision of the Monarchs went into effect 8 February 1505. The tribunal had jurisdiction and extraordinary privileges not only in Andalusia but in the kingdoms of Granada and Murcia, the provinces of Extremadura and La Mancha, and the Canary Islands.       

The seat of the high court is still the Real Chancillería, though the building has undergone numerous transformations over the course of history. 

In 1834 the Chancellery was renamed Audiencia (Court), with jurisdiction over the provinces of Granada, Almeria, Jaen and Malaga. Also created was the Territorial Court of Seville, with jurisdiction over four western provinces: Seville, Huelva, Cadiz and Cordoba.